| Message: | Estrone
Synonyms: 1,3,5(10)-Oestratrien-3-ol-17-one
CAS NO: 53-16-7
Molecular Formula: C18H22O2
Molecular Weigh: 270.371
CAS NO: 53-16-7
Standard: USP30
Appearance: white or almost white powder
Usage: A metabolite of 17beta-Estradiol.
Estrone (E1, and also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is an odorless, solid crystalline powder, white in color with a melting point of 254.5 °C and a specific gravity of 1.23.[1][2][3] Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.
Estrone is known to be a carcinogen for human females as well as a cause of breast tenderness or pain, nausea, headache, hypertension, and leg cramps in the context of non-endogenous exposure.[1][4] In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile dysfunction.[2] Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women.[5]
Estrone was discovered and isolated by German chemist Adolf Butenandt. |
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