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CAS NO:55-06-1
Chemical name:3,3',5-Triiodo-L-thyronine, sodium salt
Molecular formula:C15H12I3NO4
Molecular Weight:650.97
Content:(%):99
Boiling point:205°C
water-solubility:4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
Usage : It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate, such as, treatment of depressive disorders and use as a fat loss supplement.
Treatment of depressive disorders:
The addition of triiodothyronine to existing treatments such as SSRIs is one of the most widely studied augmentation strategies for refractory depression,however success may depend on the dosage of T3. A long-term case series study by Kelly and Lieberman of 17 patients with major refractory unipolar depression found that 14 patients showed sustained improvement of symptoms over an average timespan of two years, in some cases with higher doses of T3 than the traditional 50 µg required to achieve therapeutic effect, with an average of 80 µg and a dosage span of 24 months; dose range: 25-150 µg.The same authors published a retrospective study of 125 patients with the two most common categories of bipolar disorders II and NOS whose treatment had previously been resistant to an average of 14 other medications. They found that 84% experienced improvement and 33% experienced full remission over a period of an average of 20.3 (standard deviation of 9.7). None of the patients experienced hypomania while on T3.
Use as a fat loss supplement:
3,5-Diiodo-L-thyronine and 3,3'-diiodo-L-thyronine are used as ingredients in certain over-the-counter fat-loss supplements, designed for bodybuilding. Several studies have shown that these compounds increase the metabolization of fatty acids and the burning of adipose fat tissue in rats.
Applications:
Intended use
Immunoassay for the in vitro quantitative determination of free triiodothyronine in human serum.
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