| Message: | Betamethasone
CAS No.:378-44-9
Another Name:Betamethasone base; 9a-fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione; 9alpha-fluoro-16beta-methylprednisolone; 9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; (11beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
EINECS NO.:206-825-4
Molecular Formula:C22H29FO5
Molecular Weight:392.4611
Density:1.32g/cm3
Melting Point: 235-237°C
Boiling Point: 568.2°C at 760 mmHg
Flash Point:297.5°C
Vapour Pressure: 2.81E-15mmHg at 25°C
Medical Use:Betamethasone is mainly used for anti-inflammatory and anti-allergic. Suitable for rheumatoid arthritis and various skin diseases. Role with betamethasone, dexamethasone, its anti-inflammatory effects than dexamethasone, triamcinolone, hydrocortisone strong, with few side effects.
Assay:99%
Appearance:White powder
Packaging:1kg/tin
Items Standard Results
Appearance White or almost white crystalline powder almost white crystalline powder
Identification (B,C) Complies with the Standard Complies
Specific optical Rotation +118°~+126° +125.0°
Related Substances
Single impurity Not more than 1.0% 0.51%
impurity that ≥0.5% Not more than one Complies
Sum impurities Not more than 2.0% 0.97%
Loss on drying Not more than 0.5% 0.05%
Assay(UV, basis on drying) 97.0%~103.0% 99.7%
Organic volatile substances
Methanol max. 3000ppm Complies
Ethyl acetate max. 5000ppm Complies
Acetone max. 5000ppm Complies
DMF max. 880ppm Complies
Dichloromethane max. 600ppm Complies
Chloroform max. 60ppm Complies
Packaging and storage: Preserve in tight, light-resistant containers.
Conclusion: The test product complies with the requirements of EP6.
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