| Message: | Product Name Triptorelin Acetate
Sequence Glp-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Cas No. 57773-63-4
Molecular Formula C64H82N18O13
Molecular Weight 1311.46
Purity (HPLC) 98.0% min.
Appearance? White powder
Single Impurity (HPLC)? 1.0%max
Amino Acid Composition? ±10% of theoretical
Peptide Content (N%) ?≥80.0%
Water Content(Karl Fischer)? ≤6.0%
Acetate Content (HPIC) ≤15.0%
MS(ESI) Consistent
Mass Balance? 95.0~105.0%
Specific Rotation (20/D)? -65.0～-75.0°(c=0.5 1%HAc)
Triptorelin (GnRH)
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl .
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