| Message: | 1.white endogenous estrogen metabolite steroid raw materials 2 - methoxy estradiol 98%
Quick Detail:
2 - methoxy estradiol
Product name: 2 - methoxy estradiol
CAS NO:. 362-07-2
Minor: C19H26O3
Content: 98%
Packing: 1 kg aluminum foil bag
usage: steroid raw materials
Description:
2-Methoxyestradiol is an endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. 2-Methoxyestradiol is formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. 2-Methoxyestradiol is a derivative of an oestrogenic steroidal hormone and has demonstrated:. potent inhibition of endothelial cell proliferation and migration and inhibition of bFGF and VEGF-induced corneal neovascularization in mice In MDA-MB-231 cells, 2-Methoxyestradiol inhibits HIF mediated transcriptional activation of target genes without affecting the transcription of HIF-1 pseudo itself. 2-Methoxyestradiol has been shown to induce apoptosis through activation of the p53 pathway through either activation of p38 and NF-B or JNK and AP-1 both leading to Bcl-2 phsophorylation. In addition the compound has also been observed to upregulate death |
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