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Spironolactone
EINECS:200-133-6
Molecular Formula:C24H32O4S
CAS Registry Number:52-01-7
Synonyms:Alderon; 3-(3-Keto-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alph a.-yl)propionic acid lactone; Uractone;
Chemical Properties
Appearance:White powder.
Molecular Weight:416.57
Density:1.24g/cm3
Boiling Point:597℃ at 760mmHg
Melting Point:198-207℃
Flash Point:302.3℃
Alpha:-37 ° (C=1, CHCL3)
Storage Temperature:Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Refractive index:-36 ° (C=1, CHCl3)
Solubility:practically insoluble
Biological Activity:Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo . Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
Stability:Stable under normal temperatures and pressures.
Usage:It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypok. |
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