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Estradiol benzoate
Synonyms: (17beta)-Estra-1,3,5(10)-triene-3,17-diol 3-benzoate;1,3,5(10)-Estratriene-3,17-diol-3-benzoate;1,3,5(10)-Oestratriene-3,17-beta-diol 3-benzoate;1,3,5(10)-oestratriene-3,17-beta-diol3-benzoate;17beta-Estradiol monobenzoate;17-beta-estradiolmonobenzoate;17-beta-Oestradiol 3-benzoate;17-beta-oestradiol3-benzoate
CAS: 50-50-0
MF: C25H28O3
MW: 376.49
EINECS: 200-043-7
Chemical Properties White solid
Usage antiacne, antineoplastic
Usage Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an
estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the
treatment of lesions produced by diminution of bodily production of estrogens.
Description:
Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is
the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog
which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to
induce estrus in domestic livestock. This compound binds to the human and murine estrogen receptor
α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction
in binding affinity compared to estradiol.
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