| Message: | SR9011
Cas No.: 1379686-29-9
Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
Formula: C23H31ClN4O3S
Molucelar weight: 479.03524
Mini order: Only 5g, 10g
Package: Super discreet to ensure 100% pass rate
Stock now: Mass and plenty---Prompt shipment
Payment: T/T, Bank Transfer, Western Union, Paypal, Money Gram and Bitcoin
Lead time: Within 12 hours upon receipt of payment
Delivery: All Express Modes (EMS, DHL, TNT, FedEx, UPS, etc.)
Shipping time: 3-7 days by express door-to-door
Description and Applications:
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols.
Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.
The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
How to Use SR9011?
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
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