| Message: | CAS 2529-45-5 No Side Effect Anti- Inflammatory Glucocorticoid Steroids Flurogestone Acetate
Quick Detail:
Product name Flurogestone acetate Factory Supplying
Other name Flugestone 17-acetate; fluorogesteroneacetate
CAS register number 2529-45-5
Molecular formula C23H31FO5
Molecular weight 406.49
Molecular structure
Melting point 255-256.5¡ãC
Assay 98%
Description:
Fluorogestone Acetate (also known as Flurogestone Acetate, Flugestone Acetate, Fluorogesterone Acetate) was first synthesised by G. D. Searle and Company in 1959. The chemical, which has progestogen activity, was identified as SC-9880. The use of SC-9880 in an intravaginal device for the control and synchronization of oestrus in sheep was described by Wishart
Fluorogestone acetate showed a high potency with short duration of activity and performed physiologically similar to progesterone. FGA was approximately 20 - 25 times more potent than progesterone. Flurogestone acetate was shown to be readily absorbed from impregnated sponges . A 30mg impregnated sponge was effective in blocking ovulation and oestrus, once the sponge was removed impregnated ewes showed visible oestrus, and if inseminated 2 to 4 days after sponge removal showed high conception rates.
COA :
Product name Flurogestone acetate
Appearance White crystalline powder
Chromatographic purity Any individual impurity not more than 1.0% Total impurities not more than 2.0% 0.4% 1.3%
Loss on drying Not more than 0.5% 0.2%
Residue on ignition Not more than 0.2% 0.03%
Residual solvents Methanol¡Ü3000ppm Methylene Chloride¡Ü600ppm Chloroform¡Ü60ppm Tetrahydrofuran¡Ü720ppm 370ppm Not detect out Not detect out Not detect out
Assay Between 97.0% and 102.0% 99.3%
Micronixation 90% not more than 10 microns 90% not more than 10 aicrons
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