| Message: | pentadecapeptide BPC 157
Function:Blood System Agents
Certification:GMP
pentadecapeptide BPC 157 Grade Standard:Medicine Grade
pentadecapeptide BPC 157 Type:Chemical Reagent
pentadecapeptide BPC 157 State:Solid
pentadecapeptide BPC 157 Volatile:Not Volatile
Product Name:Pentadecapeptide Bpc 157
pentadecapeptide BPC 157 Appearance:White Solid Powder
pentadecapeptide BPC 157 Assay:99%
pentadecapeptide BPC 157 Package:2mg/vial
Abstract
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H2O2 stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts.
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