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English Synonyms: Dienogestrel;Dienogest;(17a)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile;17a-Cyanomethyl-17-hydroxyestra-4, 9-dien-3-one;Dienogestril;Endometrion;STS 557;(17R)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
CAS NO.: 65928-58-7
Assay: 98%
Molecular Formula:C20H25NO2
Molecular Weight:311.42
Packing:foil bag
Usage: Dienogest newly developed contraceptive drug, due to its strong inhibition of ovulation and used oral contraceptives
Appearance: White crystalline powder
Product Description
Application:
For the treatment of endometriosis .Dienogest is used primarily as a contraceptive in combination with ethinylestradiol.
It is given as a tablet containing 2 mg of dienogest and 30 μg of ethinylestradiol. Dienogest is also available in a quadriphasic
oral contraceptive pill combined with estradiol valerate, marketed as Natazia in the United States and Qlaira in some European countries.
This formulation is also approved for the treatment of heavy menstrual bleeding.
The minimum dose required to inhibit ovulation has been found to be approximately 1 mg.
Explanation:
Dienogest was synthesised in 1979 in Jena, Germany under the leadership of Prof. Kurt Ponsold, was initially referred to as STS 557.
It was found that its potency was 10 times that of levonorgestrel. The first product on the market to contain dienogest as a contraceptive pill
Valette in 1995 made by Jenapharm. It has been little used outside of Germany.
Dienogest is an orally-active semisynthetic, steroidal progestogen (or progestin). It is available for use as an oralcontraceptive in combination
with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenicsymptoms. It is a non-ethinylated progestin which is
structurally related to testosterone. Dienogest given in isolation is available for the treatment of endometriosis under the trade name Visanne.
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