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CAS No.: 721-50-6
Name: Propanamide, N-(2-methylphenyl)-2-(propylamino)-
Formula: C13H20N2O
Molecular Weight: 220.31
Synonyms: o-Propionotoluidide,2-(propylamino)- (6CI,8CI);2-Methyl-a-propylaminopropionanilide;Astra 1512;Astra 1515;Citanest;N-(2,6-Dimethylphenyl)-2-(propylamino)propanamide;NSC 40027;Propitocaine;o-Methyl-2-propylaminopropionanilide;
EINECS: 211-957-0
Density: 1.029 g/cm3
Boiling Point: 361.6 °C at 760 mmHg
Flash Point: 134.3 °C
Application: Anesthetic(local)
Description
As a local anesthetic of the amino amide type, it is first prepared by Claes Tegner and Nils L? Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia.
In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.
Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to hydrophobic group (aromatics) on the other side.
Local anesthetics, long duration, lower toxicity, chemicals that are also small Suitable for epidural anesthesia, block anesthesia and infiltration anesthesia, etc. |
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