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Pirfenidone
Pirfenidone
Synonym:Pirfenidone;amr-69; amr69;5-Methyl-1-phenyl-2-(1H)-pyridone
CAS#53179-13-8
MW:185.22
MF:C12H11NO
Purity:99.5%(HPLC)
Solubility:H2O: >10 mg/mL at 60 °C (warming for 30 minutes);DMSO: >20 mg/mL
Apprarance:White Powder
Application:
(pirfenidone) is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.
Dose:
At the recommended dosage of 2403 mg/day, 14.6% of patients on compared to 9.6% on placebo permanently discontinued treatment because of an adverse event. The most common ( > 1%) adverse reactions leading to discontinuation were rash and nausea. The most common ( > 3%) adverse reactions leading to dosage reduction or interruption were rash, nausea, diarrhea, and photosensitivity reaction.
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