| Message: | CAS NO:9005-65-6 Tween 80
IUPAC name:Polyoxyethylene (20) sorbitan monooleate
Other names:Alkest TW 80,Tween 80
CAS Registry Number:9005-65-6
Chemical formula:C64H124O26
Molar mass:1310 g/mol
Appearance:Amber colored viscous liquid
Density:1.06–1.09 g/mL, oily liquid
Boiling point: > 100°C
Solubility in water:Very soluble
Solubility in other solvents:soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene
Viscosity:300–500 centistokes (@25°C)
Uses
Food use
Polysorbate 80 is used as an emulsifier in foods.
For example in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting. Adding this substance prevents milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Health and beauty use
Polysorbate 80 is also used as a surfactant in soaps and cosmetics, or a solubilizer such as in a mouthwash. The cosmetic grade of polysorbate 80 may have more impurities than the food grade.
Medical use
Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the manufacture of the popular antiarrhythmic amiodarone. It is also used as an excipient in some European and Canadian influenza vaccines.Influenza vaccines contain 25 μg of polysorbate 80 per dose. It is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
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