| Message: | Phenacetin;1-Acetamido-4-ethoxybenzene;Para-Acetophenetidide;p-Acetophenetidine;p-Acetophenetide;p-Acetphenetidin;Paracetophentidin;p-Ethoxyacetanilide
Molecular formula : C10H13NO2
MW : 179.220
CAS No. :62-44-2
preparation methods : (a) by the right-phenetidine derived by acetylation. Will benzene, acetic anhydride and right-phenetidine mixture of the oil bath azeotropic 4h on heating, cooling response after response, that is, non-precipitation that statins, filtering, cold benzene washing, drying is in production for the theory of 86%. (2) Acetaminophen and ethanol derived sodium role : first right acetylamino phenol sodium increases in ethanol, then slowly by adding iodine ethane, returning 1h heating, cooling, filtration, from crude ethanol-soluble, filtered and the filtrate diluted with hot water, then cooling, filtration, dry products generated from production theory of 80%. The first method would not have benzene solvent, with the acid substitution, process is as follows. 40% of the dilute acid heated to a boil, put right-phenetidine, steaming to water until the temperature rose to 150 ° C by adding acetic acid reflux 1h, continue to steam until the temperature rose to above 150 ° C, samples of free-phenetidine, according to residual volume-phenetidine joined acetic anhydride. refluxed 0.5h, inspection finish after passing decompression, recovery to amino acid content in the following 0.046, following a 0.2% acid, into the thermal hydraulic response of refined liquor, stir down to 40 ° C, filtering, in-phenacetium crude. Refining, phenacetium increase crude or refined liquor boiling water, stirring heated dissolution, filtration, liquid acid used to adjust pH data, by adding activated carbon and sodium thiosulfate mixing bleaching, filtration, liquid cooling crystallization rejection filter, air drying, in non - phenacetium.
purposes : acetaminophen phenetidine raw materials used for organic synthesis and drug intermediates. |
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