| Message: | CAS 50-27-1 Estriol/sherry@chembj.com
Product Name: Estriol
CAS: 50-27-1
EINECS: 200-022-2
MF: C18H24O3
MW: 288.38
Packing: Foil Bag
Standards: USP27
Appearance: White Crystalline Powder
Usage: A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol.
Estriol (also oestriol or E3) is one of the three main estrogens produced by the human body.
Estriol is only produced in significant amounts during pregnancy as it is made by the placenta from 16-hydroxydehydroepiandrosterone sulfate (16-OH DHEAS),an androgen steroid made in the fetal liver and adrenal glands.
The human placenta produces pregnenolone and progesterone from circulating cholesterol. Pregnenolone is converted in the fetal adrenal gland into dehydroepiandrosterone (DHEA), a C19 steroid, then subsequently sulfonated to dehydroepiandrosterone sulfate (DHEAS). DHEAS is converted to 16-OH DHEAS in the fetal liver. The placenta converts 16-OH DHEAS to estriol, and is the predominant site of estriol synthesis.
Levels of estriol in non-pregnant women do not change much after menopause, and levels are not significantly different from levels in men.
In pregnant women with multiple sclerosis, estriol reduces the disease's symptoms noticeably,according to researchers at UCLA's Geffen Medical School.
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