| Message: | CAS 4759-48-2 Isotretinoin/sherry@chembj.com
Product Name: Isotretinoin
Synonyms: Isoretinoin,Isotrex,Neovitaminaacid,RoaccutaneTeriosal,Lsotretinoin,Accutane
CAS: 4759-48-2
EINECS: 225-296-0
MF: C20H28O2
MW: 300.44
Melting Point: 172-175 ℃
Application: drug for skin use
Grade: Pharmaceutical Grade
Appearance: Orange Red Crystal
Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include: muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.
In the United States a special procedure is required to obtain the pharmaceutical. In most other countries a consent form is required which explains these risks. Women taking isotretinoin must not get pregnant during, and for 1 month after isotretinoin therapy. Sexual abstinence, or effective contraception is mandatory during this period. Barrier methods by themselves (such as condoms) are not considered adequate due to the unacceptable failure rates of approximately 3%. Women who fall pregnant whilst on isotretinoin therapy are generally counselled to have a termination. Isotretinoin has no effect on male reproduction.
In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.
|
my account
