| Message: | CAS 59122-46-2 Misoprostol/sherry@chembj.com
Product Name: Misoprostol
CAS: 59122-46-2
MF: C22H38O5
MW: 382.54
Purity: 98%
MP: 261-263℃
HS Code: 3001200010
Package: 1kg/aluminium foil bag
Appearance: White Solid
Biological Activity:Cytoprotective prostaglandin E 1 analog that displays agonist activity at EP receptors. K i values are 120, 250, 67 and 67 nM at cloned mouse EP 1 , EP 2 , EP 3 and EP 4 receptors respectively. Prevents NSAID-induced gastric ulceration.
Application: Misoprostol is a synthetic analogue of E1, its role is to make the woman's uterus muscles and tissues become loose, in order to achieve increased cervix dilation purposes, safe way to terminate pregnancy.
Misoprostol Usage
Misoprostol is approved for use in the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).
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