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Eptifibatide

Create: 02/23/2017
Expired Date:never
Category: Ketone intermediates [Chemical]
Message:Product Name Eptifibatide; Sequence? Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 Cas No. 148031-34-9 Molecular Formula C35H49N11O9S2 Molecular Weight 832.4 Appearance White slightly yellwish powder Specific Rotation[20/D] -75.0~-95.0°(C=1,1%HAc) Amino Acids composition ± 10% Peptide Purity (By HPLC) ≥98% by area integration Related Substance (By HPLC) Total Impurities (%)≤2.0%? Largest Single Impurity (%)≤ 1.0% Water Content (Karl Fischer) ≤8.0% Peptide Content(N determination) ≥80% Acetate Content ≤15% IR spectrum in accordance Brief introduction: Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.[1] Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the so-called arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market. Indications Eptifibatide is used to reduce the risk of acute cardiac ischemic events (death and/or myocardial infarction) in patients with unstable angina or non-ST-segment-elevation (e.g., non-Q-wave) myocardial infarction (i.e., non-ST-segment elevation acute coronary syndromes) both in patients who are to receive non surgery (conservative) medical treatment and those undergoing percutaneous coronary intervention (PCI).
City:Wuhan Hubei[CN] 
Location:
 
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