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Vapreotide Acetate

Create: 02/23/2017
Expired Date:never
Category: Ketone intermediates [Chemical]
Message:Product Name Vapreotide Acetate Sequence D-Phe-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2   Cas No. 103222-11-3 Molecular Formula C57H70N12O9S2 Molecular Weight 1131.40 Purity (HPLC) 98.0% Appearance? White powder Single Impurity(HPLC)? 1.0% Amino Acid Composition? 10% of theoretical Peptide Content(N%) 80%(by %N) Water Content(Karl Fischer)? 6.0% Acetate Content(HPIC) 15.0% MS(ESI)   Mass Balance? 95.0~105.0% 2. Description: Variceal bleeding is a life-threatening complication of portal hypertension. The recommended treatment includes the early administration of a vasoactive drug. Vapreotide is a somatostatin analogue with a different receptor affinity to octreotide. It decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis. The pivotal study of early administration of vapreotide in patients with cirrhosis and variceal bleeding has shown a significant improvement in bleeding control and, in the subset of patients with significant bleeding, a significant reduction in mortality. In addition, a meta-analysis of four randomized studies has shown a significant improvement in bleeding control. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects. 3. Application: The immediate release formulation of Sanvar, a somatostatin analogue, is used in the treatment of acute esophageal variceal bleeding (EVB).
City:Wuhan Hubei[CN] 
Location:
 
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