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Anti-Cckbr immunotoxin (scFv)-PE |
| Create: 02/27/2017 |
| Expired Date: | 02/06/2020 |
| Category: | Drugs&Pharmaceutical [Health&Medical&Pharmaceutical] |
| Message: | This immunotoxin was achieved by conjugating/fusing the Anti-Cckbr scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to gastrin/cholecystokinin subtype 2 receptor (CCK2R) overexpressed gastric cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating gastric cancer. |
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| City: | Shirley[US]
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| Location: |
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