| Message: | This immunotoxin was achieved by conjugating/fusing the Anti-CCR4 scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CCR4+ tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of T-cell acute lymphoblastic leukemia (ALL); adult T-cell leukemia/lymphoma (ATLL); adult peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL).
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