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Anti-CD24 immunotoxin SWA11 (IgG)-PE

Create: 02/27/2017
Expired Date:02/22/2023
Category: Drugs&Pharmaceutical [Health&Medical&Pharmaceutical]
Message:This immunotoxin was achieved by conjugating/fusing the Anti-CD24 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD24-expressing colorectal cancer (CRC) cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating colorectal cancer.
City:Shirley[US] 
Location:
 
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