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Anti-CD276 immunotoxin 8H9 (scFv)-PE |
| Create: 02/27/2017 |
| Expired Date: | 02/15/2019 |
| Category: | Drugs&Pharmaceutical [Health&Medical&Pharmaceutical] |
| Message: | This immunotoxin was achieved by conjugating/fusing the Anti-CD276 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively bind to a cell surface glycoprotein expressed on human breast cancers; childhood sarcomas; and neuroblastomas. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating human breast cancers; childhood sarcomas and neuroblastomas. |
| City: | Shirley[US]
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| Location: |
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