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Anti-CD38 immunotoxin IB4 (IgG)-Sap

Create: 02/27/2017
Expired Date:02/16/2018
Category: Drugs&Pharmaceutical [Health&Medical&Pharmaceutical]
Message:This immunotoxin was achieved by conjugating/fusing the Anti-CD38 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD38+ cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Non Hodgkin lymphoma (NHL).
City:Shirley[US] 
Location:
 
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