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Anti-IGHE (Fab-RTA) immunotoxin

Create: 03/30/2017
Expired Date:03/22/2019
Category: Drugs&Pharmaceutical [Health&Medical&Pharmaceutical]
Message:This immunotoxin was achieved by conjugating/fusing the Anti-IGHE Fab to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells bearing the IgE isotype. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Allergy.
City:Shirley[US] 
Location:
 
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