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BAFF-DT immunotoxin

Create: 03/30/2017
Expired Date:03/12/2019
Category: Drugs&Pharmaceutical [Health&Medical&Pharmaceutical]
Message:This immunotoxin was achieved by conjugating/fusing the BAFF to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to BCMA expressing B cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of B cell leukemias.
City:Shirley[US] 
Location:
 
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