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transferrin-Sap immunotoxin

Create: 03/30/2017
Expired Date:03/08/2019
Category: Drugs&Pharmaceutical [Health&Medical&Pharmaceutical]
Message:This immunotoxin was achieved by conjugating/fusing the transferrin to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TFRC expressing cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.
City:Shirley[US] 
Location:
 
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