| Message: | Anabolic Tibolone 23454-33-3 Raw Steroid Livial Powder
Description:
Tibolone （Steroids）
Synonyms: TIBOLONE; LIVIELLA; LIVIAL
CAS: 5630-53-5
EINECS: 227-069-1
Assay: 99% min.
Packing: 1kg/foil bag.
Delivery: Express courier.
MF: C21H28O2
MW: 312.45
MS:
Character: White powder.
MP: 169.
Usage: pharmaceutical material, Steroid hormone, Anabolin. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
Applications:
In itself Tibolone has no biological activity; the effects are produced mainly by the results of the activity of its metabolites on various tissues. After administration, Tibolone is quickly metabolized into 3¦Á-hydroxytibolone and 3--hydroxytibolone compounds, which are also present in an inactive, sulfated form. A third compound, the ¦¤4- isomer is formed from Tibolone directly or from the 3h hydroxymetabolite.
Tibolone has estrogenic effects on bone and vaginal tissue. The ¦¤4-isomer functions as a progestogen in endometrial tissue, whereas in the brain and liver it has androgenic effects.In breast tissue, Tibolone acts by strongly inhibiting sulfate activity and weak inhibition of 17¦Á-hydroxysteroid dehydrogenase activity, which results in blocking the conversion of estrone sulfate to E2.
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