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Product Name: Citicoline
Alias: CDP Choline
CAS: 987-78-0
EINECS: 213-580-7
MF: C14H26N4O11P2
MW: 488.32
Purity: 99%
Grade: Pharmaceutical Grade
Appearance: White Powder
Memory Disorders
In a review of 14 clinical trials, the authors concluded there was evidence of benefit of citicoline on memory function and behaviour in patients suffering from cognitive deficits ranging from mild cognitive impairment to dementia. Dosing in most of the trials was 1000 mg/day. A more recent review reached the same conclusions, but went on to state that more clinical trials are needed to confirm its benefits.
Mechanism of Action
The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine, partial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.
Citicoline's effects may also be explained by the reduction of phospholipase A2 activity. Citicoline increases phosphatidylcholine synthesis. The mechanism for this may be: By converting 1, 2-diacylglycerol into phosphatidylcholine, stimulating the synthesis of SAMe, which aids in membrane stabilization and reduces levels of arachidonic acid. This is especially important after an ischemia, when arachidonic acid levels are elevated.
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