| Message: | Ethinyl estradiol (EE2), also sometimes written as 17α -ethinyl estradiol, ethinylestradiol, ethynyl estradiol, or ethinyl? Stradiol, is a derivative of 17β -estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose.
Transdermal ethinyl estradiol carries a greater risk of clot formation and venous thromboembolism than naturally occurring 17β -estradiol, which some have theorized to be related to different amounts of hepatic metabolism after absorption. The same contraindications and precautions apply for EE2 as with other estrogen medications.
Estinyl was a preparation of EE2 alone that was used for the management of menopausal symptoms and female hypogonadism.
EE2 is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication.
The major concern with unopposed estrogen (without progestogen) is of endometrial cancer. As such, the medication is generally prescribed with progesterone in the setting of birth control.
EE2 is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives. Over time, formulations have decreased the EE dose from as high as 100 μ G to as low as 10 μ G in LoLoestrin Fe.
3. Direction
Usage: Oral
Dosage: Germinal aplasia; One time 0.02~0.05mg, one time every night, last 3 weeks. Third weeks with progesterone artificial cycle therapy, available from 1 to 3 cycles;
Climacteric syndrome; 0.02~0.05mg every day, last 21 days
Breast cancer; One time 1mg, 3 times every day
Prostatic cancer; One time 0.05~0.5mg, 3 -6 times every day
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