| Message: | Product Name:Pentadecapeptide
Alias : BPC 157
CAS : 137525-51-0
MF : C62H98N16O22
MW : 1419.53552
Specification : 2mg/vial
Appearance : White Lyophilized Powder
Description:
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence
of body protection compound (BPC) that is discovered in and isolated from human gastric juice.
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth,
cell survival, and cell migration
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects.
Application:
1. BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.
2. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
3. FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
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