| Message: | Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcription repression or activation. HMTs transfer 1-3 methyl groups from S-adenosyl-L-methionine to the lysine and arginine residues of histone proteins. Inhibition of HMTs may lead to expression of the silenced genes, and HMT inhibitors are currently developed for various therapeutic or experimental applications. SET1, SET7/9, Ash1, ALL-1, MLL, ALR, Trx, and SMYD3 are histone methyltransferases that catalyze methylation of histone H3 at lysine 4 (H3-K4) in mammalian cells. H3-K4 methylation may serve as a epigenetic mark in euchromatin and mediates activated transcription. There is only the radioisotopic method currently available for measuring HMT activity/ inhibition, which is time consuming, labor-intensive, and has low throughput or produces radioactive waste. The Histone Methyltransferase Activity/ Inhibition Assay Kit (H3-K4) addresses these problems by using a unique procedure to measure HMT activity/ inhibition.
https://www.creativebiomart.net/histone-methyltransferase-activityinhibition-assay-kit-h3-k4-463122.htm |
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