| Message: | PEG MGF 2mg Per Vial White Powder
1.basic info:
Alias: PEG-Suc-YQPPSTNKNTKSQ(d)R(d)RKGSTFEEHK-NH2; PEG-Suc-Tyr-Gln-PRO-PRO-Ser-Thr-Asn-Thr-Lys-Ser-Gln-D-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
M.F.: C121H200N42O39
Purity (HPLC): 98.0%
Single Impurity(HPLC): 0.5%max.
Amino Acid Composition: about 10% of theoretical
Peptide Content(N%): 80.0%min.
Water Content(Karl Fischer): 8.0%max.
Acetate Content(HPLC):10.0%max.
Specific Rotation: (20/D) -55.0 ~ -65.0 dgree(c=1 1%HAc)
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Bacterial Endotoxins: 5 EU/mg max.
Appearance: White powder
2.PEG-MGF Usage:
Mechano Factor (MGF) exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic Mechano Factor (MGF) is that it is introduced intramuscularly and is water based so it goes into the blood stream. When used this way, Mechano Factor (MGF) only remains stable in the blood stream for a few minutes. Biologically produced MGF is made locally and does not enter the bloodstream. It is also short acting so stability is not an issue. By PEGylating the Mechano Factor (MGF) it is almost as efficient as local produced Mechano Factor (MGF) when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. The polyethylene glycol groups protect the peptide but do not surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein.
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