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Product introduction
Ethinylestradiol
Synonyms: NOVESTROL; NEO-ESTRONE; ETHYNYLESTRADIOL
Ethinylestradiol CAS No: 57-63-6
Ethinylestradiol Molecular Weight: 296.41
Ethinylestradiol Molecular Formula: C20H24O2
Ethinylestradiol Standard: USP28
Ethinylestradiol Purity:99%
Ethinylestradiol Origin: China
Ethinylestradiol Appearance: White Powder
Usage: A synthetic steroid with high oral estrogenic potency
thinylestradiol USAGE :
Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later. It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme.
Ethinyl Estradiol and its metabolites are excreted with the bile. Due to the effect of entero hepatic circulation a second peak is seen several hours later. Individually, wide variations exist in the overall absorption process, and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes.
In circulation Ethinyl Estradiol is almost fully bound to plasma albumin. It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.
Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives. Over time, formulations have decreased the Ethinyl Estradiol dose from as high as 100 μg to as low as 10 μg in
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