| Message: | Tamoxifen
Product Name: Tamoxifen
Synonyms: (z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)phenoxy)-n,n-dimethylethanamine;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylamine;1-para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene;1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene;ici47699;n-dimethyl-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-(z)-ethylamin;Nolvadex-D;tamoxifen(z)
CAS: 10540-29-1
MF: C26H29NO
MW: 371.51
EINECS: 234-118-0
Chemical Properties: White Crystalline Solid
Usage :A nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines
Usage: Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response mo difiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. |
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