| Message: | Product Name: Intedanib
Synonyms: Intedanib;Vargatef;Nintedanib;Nintedanib (BIBF 1120);Nintedanib/Intedanib/Vargatef;Intedanib Vargatef;methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate Nintedanib (BIBF 1120);Vargatef (nintedanib)
CAS: 656247-17-5
MF: C31H33N5O4
MW: 539.62482
Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Purity : 99%
Appearance : Pale yellow powders
Package : 1kg/ foil bag
Usage It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors.
Usage BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
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