| Message: | Product Name: BIBW 2992
Synonyms: BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW 2992);ToMtovok;(S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
CAS: 439081-18-2
MF: C24H25ClFN5O3
MW: 485.944
Product Categories: API
density 1.380
Usage: BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.
About Afatinib:
Afatinib is a form of biological therapy called a tyrosine kinase inhibitor (TKI). It's a treatment for non small cell cancer of the lung that has spread outside the lung or to other parts in the body.
How afatinib works
This kind of drug works by blocking particular proteins on cancer cells that let the cancer to grow. Afatinib blocks proteins called epidermal growth factor receptors (EGFR). Cancers which may have these receptors are known as EGFR positive. |
my account
