| Message: | •Anastrozole
•Alias :Arimidex ,Tetramethyl-5-(1H-1,2,4-triazol-1ylmethyl)1,3-benzenediacetionitrile
•CAS NO. : 120511-73-1
•Assay : 98%~102%
•Appearance : White crystalline powder
•Active life cycle : 6 hours
•MF : C17H19N5
•MW : 293.37
•Grade : Pharmaceutical Grade
•Storage: Shading, confined preservation
•Manufacturer : Hezhong
•Usage : Anastrozole is a potent non-steroidal aromatase inhibitors , which lead the decrease of plasma level of estrogen, inhibited the growth of breast cancer. For the treatment of advanced breast cancer in postmenopausal women patients.
Description :
Anastrozole is a drug indicated in the treatment of breast cancer in post-menopausal women. It is used both in adjuvant therapy (i.e. following surgery) and in metastatic breast cancer.
Many breast cancers also contain aromatase; the importance of tumor-generated estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone.
Application:
Three azole aromatase inhibitors are potent selective, it can inhibit the cytochrome P-450 dependent aromatase thereby blocking the biosynthesis of estrogen, but estrogen is the main factor that stimulates the growth of breast cancer cells.
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