| Message: | Product Name: DSIP
CAS: 62568-57-4
MF: C35H48N10O15
MW: 848.81
Storage temp: -20°C
Specification: 2mg/vial
Appearance: White Lyophilized Powder
Description:
DSIP (Delta Sleep-inducing Peptide) is a neuropeptide found in the hypothalamus, pituitary, and adrenal glands.Its isolation has allowed for extensive research which has found several possible primary and peripheral roles of this peptide. First, DSIP has been shown to induce sleep.Second, it may have benefits as an analgesic in treatment of chronic pain, sometimes as an adjunct treatment. Third, DSIP has been shown to block ACTH release and decrease levels of ACTH, stimulate LH release, and act as an inhibitor of the secretion of somatostatin.
The source of production of DSIP is yet unknown; It may be produced in the central nervous system or in a peripheral organ. It is thought to pass. Through the blood-brain barrier (BBB) more easily than most known neuropeptides. As mentioned, DSIP has shown positive results in inducing slow-wave EEG (sleep). It has been shown to help treat narcolepsy and restore disturbed sleep patterns to normal sleep rhythms.
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon. In the brain its action may be mediated by NMDA receptors. In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats. It is unknown where DSIP is synthesized.
In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule, but as yet no structure or gene has been found for this precursor.
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