| Message: | Follistatin, also called activin-binding protein, is found in nearly all tissues of vertebrate animals. Its primary function is to neutralize members of the TGF-β family, which play fundamental roles in everything from growth and development to energy homeostasis and immune system regulation. In particular, follistatin interacts with activin, which plays an important part in cell proliferation and cell death as well as in the immune response as it applies to wound repair.
Follistatin 344 and 315 are engineered analogues of naturally occurring follistatin. Both are created by alternative splicing of the follistatin mRNA transcript. Scientific research in non-human primates as well as in mice have indicated that both molecules are capable of improving muscle growth by antagonizing myostatin (a member of the TGF-β family). |
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