PEN2 Peptide

Create: 12/25/2018

Expired Date:	never
Category:	Medical testing [Health&Medical&Pharmaceutical]
Message:	Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. https://www.creative-diagnostics.com/PEN2-Peptide-184427-436.htm.






City:	Shirley[US]
Location:

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