| Message: | Epigenetic activation or inactivation of genes plays a critical role in many important human diseases, especially in cancer. A major mechanism for epigenetic inactivation of the genes is methylation of CpG islands in genome DNA caused by DNA methyltransferases. Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcription repression or activation. HMTs transfer 1-3 methyl groups from S-adenosyl-L-methionine to the lysine and arginine residues of histone proteins. SET1, SET7/9, Ash1, ALL-1, MLL, ALR, Trx, and SMYD3 are histone methyltransferases that catalyze Methylation of histone H3 at lysine 4 (H3-K4) in mammalian cells. H3-K4 methylation may serve as a epigenetic mark in euchromatin and mediates activated transcription. Increased H3-K4 methylation is also found to be involved in some pathological processes such as cancer progress. There are only a few methods such as western blot used for measuring histone H3-k4 methylation. The methods available so far are time consuming, labor intensive, or have low throughput. The Histone H3-K4 Methylation Assay Kit addresses these problems by using a unique procedure to measure methylation of histone H3-K4.
https://www.creativebiomart.net/histone-h3-k4-methylation-assay-kit-463117.htm |
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