| Message: | The phosphorylation of histone H3 at serine 28 is conserved through eukaryotes, and an increase in phosphorylation has been shown to correlate with gene activation and cell growth. In vitro studies have shown that phosphorylation of histone H3 at both ser10 and Ser28 is coupled to dynamic acetylation of histone H3, where H3 phosphorylated at serine 28 had a higher steady state of acetylation than that of H3 phosphorylated at serine 10. It was observed that histone H3 phosphorylation at Ser28 is regulated by the cell cycle and has been used as a mitotic marker. As with phosphorylated ser10, H3 phosphorylation at Ser28 also play an important role for neoplastic cell transformation. Several protein kinases including aurora B, PPI, and PKC are responsible for histone H3 phosphorylation at Ser28. Inhibition or activation of these protein kinases can cause a change in intracellular histone H3 phosphorylation at Ser28. Detection of the change in histone H3 phosphorylation at Ser28 associated with the cell cycle, apoptosis, and inhibitor or activator treatment, would provide useful information for better understanding the pathological processes of some diseases and for protein kinase-targeted drug development. The Histone H3 Phosphorylation (Ser28) Assay Kit (Colorimetric) provides a tool for measuring phospho histone H3 (Ser28).
https://www.creativebiomart.net/histone-h3-phosphorylation-ser28-fluorometric-assay-kit-463112.htm |
my account
