| Message: | Acetylation of histones including histone H3 has been involved in the regulation of chromatin structure and recruitment of transcription factors to the gene promoters. Histone acetyltransfeases (HAT) and histone deacetylases (HDACs) play a critical role in control of histone H3 acetylation at multiple sites. Histone H3 at lysine 18 (H3-K18), along with K9 and K14 are primary acetylated sites of histone H3. Acetylation of histone H3-K18 is tightly involved in the cell cycle regulation, cell proliferation and apoptosis. Acetylation of histone H3-K18 is also correlated with transcription activation. An imbalance in the equilibrium of histone H3 acetylation including K18 acetylation has been associated with tumorigenesis and cancer progression. Histone H3-K18 acetylation may be increased by inhibition of HDACs and decreased by HAT inhibition. Thus quantitative detection of acetyl histone H3-K18 would provide useful information for better understanding epigenetic regulation of gene activation and for developing HAT or HDAC-targeted drugs. The Acetyl Histone H3-K18 Quantification Kit (Fluorometric) provides a tool for measuring acetylation of histone H3-K18.
http://www.creativebiomart.net/Acetyl-Histone-H3-K18-Quantification-Kit-Fluorometric-462230.htm
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