| Message: | Acetylation of histones including histone H3 has been involved in the regulation of chromatin structure and recruitment of transcription factors to the gene promoters. Histone acetyltransfeases (HAT) and histone deacetylases (HDACs) play a critical role in control of histone H3 acetylation at multiple sites. Acetylation of histone H3 at lysine 36 (H3-K36) is a conserved modification, which functions in transcription. Acetylation of histone H3-K36 is tightly involved in the cell cycle regulation, cell proliferation and apoptosis. An imbalance in the equilibrium of histone H3 acetylation including K36 acetylation has been associated with cancer progression. Histone H3-K36 acetylation may be increased by inhibition of HDACs and decreased by HAT inhibition. Thus quantitative detection of acetyl histone H3-K36 would provide useful information for better understanding epigenetic regulation of gene activation and for developing HAT or HDAC-targeted drugs. The Acetyl Histone H3-K36 Quantification Kit (Colorimetric) provides a tool for measuring acetylation of histone H3- K36.
http://www.creativebiomart.net/Acetyl-Histone-H3-K36-Quantification-Kit-Fluorometric-462234.htm
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