| Message: | Acetylation of histones including histone H3 has been involved in the regulation of chromatin structure and recruitment of transcription factors to the gene promoters. Histone acetyltransfeases (HAT) and histone deacetylases (HDACs) play a critical role in control of histone H3 acetylation at multiple sites. Acetylation of histone H3 at lysine 56 (H3-K56) is cell cycle regulated, maintained upon replicative damage in a check-point dependent manner and is essential for surviving DNA damage. H3 K56 acetylation occurs normally during S phase. In the absence of this modification, cellular survival following DNA damage is impaired. Histone H3-K56 acetylation may be increased by inhibition of HDACs and decreased by HAT inhibition. Thus quantitative detection of acetyl histone H3-K56 would provide useful information for better understanding epigenetic regulation of gene activation and for developing HAT or HDAC-targeted drugs. The Acetyl Histone H3-K56 Quantification Kit (Colorimetric) provides a tool for measuring acetylation of histone H3-K56.
http://www.creativebiomart.net/Acetyl-Histone-H3-K56-Quantification-Kit-Fluorometric-462236.htm
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