| Message: | Acetylation of histones including histone H3 has been involved in the regulation of chromatin structure and recruitment of transcription factors to the gene promoters. Histone acetyltransfeases (HAT) and histone deacetylases (HDACs) play a critical role in control of histone H3 acetylation at multiple sites. Histone H3 at lysine 9 (H3-K9) is a primary acetylated site of histone H3. Acetylation of histone H3-K9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Acetylation of histone H3-K9 is tightly involved in the cell cycle reguation, cell proliferation and apoptosis. Acetylation of histone H3-K9 is also an active marker and the balance between histone H3-K9 acetylation and methylation is important for the establishment of specific chromatin structures. An imbalance in the equilibrium of histone H3 acetylation including K9 acetylation has been associated with tumorigenesis and cancer progression. Histone H3-K9 acetylation may be increased by inhibition of HDACs and decreased by HAT inhibition. Thus quantitative detection of acetyl histone H3-K9 would provide useful information for better understanding epigenetic regulation of gene activation and for developing HAT or HDAC-targeted drugs. The Acetyl Histone H3-K9 Quantification Kit (Colorimetric) provides a tool for measuring acetylation of histone H3-K9.
http://www.creativebiomart.net/Acetyl-Histone-H3-K9-Quantification-Kit-Fluorometric-462238.htm
|
my account
