| Message: | In the body, it is produced by the adrenal glands and gonads from dehyroepiandrosterone (DHEA or 17- alpha-hydroxyprogesterone). DHEA is converted into androstenedione an the enzyme in the gonads. Androstenedione is a precursor of testosterone. Once the androstenedione is taken orally, it makes it into the liver where it is almost destroyed completely, the amount that survives combine with the enzyme 17 beta-hydroxysteroid dehydrogenase to make testosterone as shown in the figure below. Taking androstenedione orally can increase androstenedione blood serum levels over 300 percent after about 2 hours and remaining high for 4 hours. Studies have shown that androstenedione by itself does not produce increased muscle mass but once converted into testosterone in the liver, the elevated testosterone levels may lead to muscle mass gain, but not proven.
The problem with androstenedione is that it metabolizes quickly into estrogens, estrone and estradiol as shown in the figure. These two products can stay in the body for days as opposed to the androstenedione, which diminishes within hours. Estrogens have an opposite effect than testosterone; they suppress fat-loss and tissue healing. Estrogen levels can be monitored and managed by blood and saliva testing in order to be kept under control if using the product.
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