| Message: | SR9009 is a research drug that was developed by Professor Thomas Burris of the Scripps Research Institute as an agonist ofRev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA)with a half-maximum inhibitory concentration (IC50) = 670 nM for Rev-ErbAα and IC50 = 800 nM for Rev-ErbAβ. Activation of Rev-erb-α by in mice SR9009 increases exercise capacity in mice by increasing mitochondria in skeletal muscle.
SR9009 Function:
A new compound called SR9009 increases metabolism, fat burning, and muscle growth in the lab. Scientists at The Scripps Research Institute (TSRI) have successfully tested a drug, called SR9009,in mice that kickstarts metabolism and results in increased muscle development. Essentially, it's an exercise regime in a pill.
SR9009 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed
[in] animals [that] are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify its metabolism.
Half of the mice studied showed improved running endurance in terms of both time and distance.
What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance.
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